This was a prospective cohort study of a convenience sample of kids getting IV ketamine for reduction of (mostly) broken arms. The child’s anxiety was measured on a scale prior to the procedure. Negative behaviours were measured by parents on another scale 1-2 weeks after discharge. There was no control or comparator group.
82 patients were analysed. 33 kids were “highly anxious” before sedation and 18 had negative behaviours after ED discharge.
The authors clearly imply that the procedural sedation itself was causal to the negative behaviours.
What about the traumatic event that caused the fracture, the pain from the injury, the wait to be seen by a doctor in a chaotic ED, the visible worry of the parents, the disruption to sleep, play, and activity from injury & plaster. Could they have potentially caused some anxiety afterward?
Evidently not… it must have been the ketamine from the procedural sedation.
This paper is shameful.
It is VERY likely the ketamine was protective of negative behaviours and changing this would have resulted in worse outcomes. When used correctly, ketamine is a wonderful drug for procedural sedation. It is incredibly safe, provides pain relief, amnesia and excellent conditions for procedures.
Covering: Pearce Ji, Brousseau DC, Yan K, et al. Behavioral Changes in Children After Emergency Department Procedural Sedation. Acad Emerg Med 2019;25:267-274. [link to article]
Dr Brian Doyle is an emergency physician originally from the United States but now very much calls Tasmania his home. Unfortunately, it will now be a bit more difficult to deport him from the country as he passed his Australian citizenship test a few years ago. (He was able to answer that Phar Lap won the Melbourne rather than the Davis Cup). His main interests are mostly the clinical aspects of emergency medicine but also in education, ultrasound and critical appraisal of the literature. He spends much of his time annoying people to help out with conferences.