But perhaps they grown them tougher in Michigan…
This randomized, double-blind, placebo-controlled trial compared haloperidol 2.5mg IV to matching placebo for ED patients with acute headache. The primary outcome measure was the change in VAS at 60 minutes.
118 patients were enrolled at a single large ED in Michigan. The trial was stopped after an unplanned interim analysis. A little bit naughty…
The reported pain dropped 4.77 units in the haloperidol group and only 1.87 in the placebo arm. Treatment with rescue ketorolac 30mg IV was required in 78% of the time with placebo and 31% with haloperidol. There were few side effects of haloperidol that were easily treated.
Ok, I willing to believe that haloperidol is better than nothing...thanks…
McCoy JJ, Aldy K, Arnall E, Peterson J. Treatment of headache in the Emergency Department: haloperidol in the acute setting (THE-HA Study): A randomized clinical trial. J Emerg Med. 2020;59:12-20. [link to article]
Dr Brian Doyle is an emergency physician originally from the United States but now very much calls Tasmania his home. Unfortunately, it will now be a bit more difficult to deport him from the country as he passed his Australian citizenship test a few years ago. (He was able to answer that Phar Lap won the Melbourne rather than the Davis Cup). His main interests are mostly the clinical aspects of emergency medicine but also in education, ultrasound and critical appraisal of the literature. He spends much of his time annoying people to help out with conferences.